dabur

Est.1979

Providing Integrated Research Solutions in Preclinical Biology

Neurology

Study Title Reference Drug End point Parameters
Anti-Nociceptive activity in the CCI-peripheral neuropathy Rat Model Gabapentin Pain sensitivity by Pressure application, % Activity
Chemotherapy Vincristine-induced Peripheral Neuropathy (CIPN) in Rats Gabapentin Pain sensitivity by Pressure application, % Activity, Cytokine estimation
MPTP induced model of Parkinson’s disease in Mice L-DOPA Pole Test, Traction Test, Dopamine level in brain , Brain Histology
Anti-dementia activity using Scopolamine induced rat/mice model Donepzil Hydrocloride Body weight, Passive Avoidance Test, Acetylcholinestrase, Neural growth factor, TNF -alpha estimation and Histopathology of Brain
Anti-dementia activity using STZ (Intracerebroventricular) induced rat/mice model Donepzil Hydrocloride Body weight, Morris Water Maze Test , Y Maze and Histopathology of Brain
Anti-anxeity activity using Elevated Plus Maze Test using Rat & Mice Diazepam Time spent in open & close arm to analyse Anxiety
Anti-depressant activity using Force swim test in Rats Imipramine Body weight, Feed intake, Actimeter, Force swim Test, Open field Test, Adrenal weight, Corticosterone estimation.
Anti-depressant activity using tail suspension test using Rat & Mice Imipramine Body weight, Feed intake, Actimeter, Elevated Plus maze, Open field Test, Corticosterone estimation.
Muscle relaxant activity using rota rod test in rat & Micel RPM-Time of Fall from Rotarod in Sec.
Learning & memory potential using Morris water maze test in Rats Time spent in NEWS zones and Time to reach hidden platform in water maze (MWM), Acetlycholine and Dopamine levele estimation to analyse memory
Anti-stress activivty using Unpredicatable Chronic Stress (UCS) Model in Rats Imipramine Body weight, Feed intake, Actimeter, Elevated Plus maze, Open field Test, Adrenal weight and Corticosterone, Serotonin, Anti-oxidant level estimation.
Learning & memory potential using Y Maze test Time spent in Center and XYZ zone, Acetlycholine and Dopamine levele estimation to analyse Leaning and Memory potential.
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