CBD

Our initial investigation on cannabidiol started in 2015 post our visit to Israel to meet with the leading scientific minds working on cannabinoids. Our scientific teams at DRF not only explored novel ways to overcome the key challenges faced while working with CBD but also investigated methods to enhance the therapeutic effects. We now work with leading companies in the US on differentiated products development with CBD and offer our own line of CBD products for commercialization in various markets.

Product Range

Serum

Creams

Capsules/Tablets

Inhaler

Tea Bags

Foods

Oral Spray

CBD Strategy

Extensive preclinical tests for efficacy and mechanism

Wide spectrum of preclinical assays to cover multiple therapeutic properties ranging from pain, immunity, inflammation to skin aging and hair growth.

Extensive testing for efficacy assessment and mechanistic profiling using cell based and animal models.

Rational selection of ingredients depending on therapeutic use

Activity guided selection of ingredients for rationally designed formulations.

Extensive characterization of products.

Formulation development: Oral or Topical

Accelerated and real time stability.

Collaborative projects.

Efficacy, permeability, bioavailability and safety tests with formulation

Testing of the technologies to ensure primary end points are achieved.

Targeted technologies adapted for customer’s requirement.

EFFICACY MODELS

ANALGESIC

  • CBD demonstrated analgesic effect by inhibition of COX-2 activity
  • CBD formulations showed >45% analgesic activity in Rat tail flick Model

ANTI INFLAMMATORY

  • CBD demonstrated anti-inflammatory activity by inhibition of inflammatory cytokines
  • CDB formulation-2 showed 42% of anti-inflammatory activity in Rat Carrageenan induced paw edema model

WOUND HEALING

  • CBD demonstrated anti-inflammatory activity by inhibition of inflammatory cytokines
  • CBD Based Cream treated group showed 66.67% activity when compared to scratch wound control

SKIN HEALTH

  • CBD demonstrated anti-aging potential by increase in fibroblasts proliferation, collagen synthesis and protection against UVB induced damage

ANTI PSORAISIS

  • CBD demonstrated anti-psoriatic potential by inhibition of keratinocytes proliferation

ANTI ACNE

  • CBD demonstrated anti-acne potential by inhibition of sebum synthesis in sebocytes

HAIR GROWTH

  • CBD demonstrated hair growth potential by increase in DPC proliferation

CHRONIC STRESS

  • CBD reduces stress and hypertensive markers

Technologies Used

  •    Nanoemulsion
  •    Polymeric Micelles
  •    Penetration Enhancers
  •    Lipid Based Nano Particles

Products

  •    Transdermal Creams & Gel
  •    Mouth Dissolving Tablets & Films
  •    Bio Nano Emulsion Based Capsules